CBD in the Treatment of PTSD
Objectives: CBD in the Treatment of PTSD. Cannabidiol (CBD) is a non-psychotomimetic cannabinoid compound that is found in plants of the genus Cannabis.
Preclinical research has suggested that CBD may have a beneficial effect in rodent models of post-traumatic stress disorder (PTSD). CBD in the Treatment of PTSD
This effect is believed to be due to the action of CBD on the endocannabinoid system. CBD has seen a recent surge in research regarding its potential value in a number of neuro-psychiatric conditions. This is the first study to date examining the clinical benefit of CBD for patients with PTSD.
Methods: This retrospective case series examines the effect of oral CBD administration on symptoms of PTSD in a series of 11 adult patients at an outpatient psychiatry clinic. CBD was given on an open-label, flexible dosing regimen to patients diagnosed with PTSD by a mental health professional. Patients also received routine psychiatric care, including concurrent treatment with psychiatric medications and psychotherapy. The length of the study was 8 weeks. PTSD symptom severity was assessed every 4 weeks by patient-completed PTSD Checklist for the DSM-5 (PCL-5) questionnaires.
Results: From the total sample of 11 patients, 91% (n = 10) experienced a decrease in PTSD symptom severity, as evidenced by a lower PCL-5 score at 8 weeks than at their initial baseline. The mean total PCL-5 score decreased 28%, from a mean baseline score of 51.82 down to 37.14, after eight consecutive weeks of treatment with CBD. CBD was generally well tolerated, and no patients discontinued treatment due to side effects.
Conclusions: Administration of oral CBD in addition to routine psychiatric care was associated with PTSD symptom reduction in adults with PTSD. CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD. Additional clinical investigation, including double-blind, placebo-controlled trials, would be necessary to further substantiate the response to CBD that was observed in this study.
Your choice of CBD isolate, full-spectrum CBD, or broad-spectrum CBD will determine what you get in your product along with the actual CBD.
- Full-spectrum CBD contains all of the naturally available compounds of the cannabis plant, including THC. However, in hemp-derived full-spectrum CBD, the THC will be no more than 0.3 percent at the dry weight. THC levels rise when the flowers are extracted into oil.
- Broad-spectrum CBD has all of the naturally occurring compounds, except all of the THC—or all but a very tiny amount–is typically removed.
- CBD isolate is the purest form of CBD, isolated from the other compounds of the hemp plant. CBD isolate should have no THC.
So, which should you choose? Some people prefer full-spectrum because they want the whole kit-and-caboodle of the cannabis plant’s benefits — with all the cannabinoids and other compounds working in synergy.
Others choose broad-spectrum because they want all the terpenes and flavonoids but no THC. Some people prefer CBD isolate because it’s tasteless and odorless, and they don’t want any other compounds included.
Cannabinoids, terpenes, and flavonoids
Now, about those compounds. What are they exactly? In addition to CBD and THC, the cannabis plant contains more than 100 cannabinoids, plus a whole bunch of other compounds called terpenes and flavonoids.
Cannabinoids go to work on your body’s endocannabinoid system. The endocannabinoid system helps keep the nervous system and immune function on an even keel.
Like cannabinoids, terpenes are another plant compound reported to have therapeutic and health-boosting benefits. And flavonoids, compounds also found in green tea and certain fruits, have been shown to protect against disease.